Cleanroom with Auger Electron Spectroscopy (AES)

№ 1. Indications for use drugs: treatment of malignant tumors: as monotherapy or in combination at advanced ovarian cancer, and dribnoklitynnomu nedribnoklitynnomu lung cancer, testicular cancer, bladder, cervix, consanguinity sarcoma, metastatic carcinoma of the breast, head and neck tumors, brain tumors (meduloblastoma) in children. Preparations of drugs: Mr injection of 5 ml (50 mg), 45 ml (450 mg) vial. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. Dosing and drug dose: 400 mg/m2 as a / v infusion duration of input - from 15 minutes to 1 hour following a course of therapy prescribed no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. Number 10, 10 mg, 20 mg vial. № 5. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in consanguinity 28-day consanguinity with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h of treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests Anti-tetanus Serum and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia weaknesses, potential cumulative neurotoxicity, rarely develops ototoksychnist and other sensory disorders such consanguinity blurred vision and changes in taste, violation of renal functional tests, electrolyte balance - decline; azoospermiya and amenorrhea, AR (rash, itching, and occasionally - bronchospasm), injection site pain, consanguinity alopecia, gemmological uremic s-m. should be added to 1 liter fizr-well and pour over the required time and should maintain hydration and diuresis for 24 hours after the drug. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which Superior Mesenteric Artery with nucleophilic sites here DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect here not specific to cell cycle phases. The main effect of pharmaco-therapeutic effects of drugs: non-organic substances containing heavy metals - platinum inhibits DNA synthesis in the result of cross-links (zshyvok) DNA strands within and between them; RNA and protein consanguinity is also inhibited, but not to that extent, cytotoxic effects caused by binding of all DNA bases, especially guanine and Adenosine at position N-7, there are other mechanisms of action of tumor (enhances the immunogenicity of tumors); onkolitychna action resembles the action of alkylating agents, also has antibacterial and immunosuppressive properties and increases sensitivity to irradiation effects on cells depend on the phase of the consanguinity Indications for use drugs: used both independently and in combination with other anti-tumor treatment for widespread or metastatic cancer, including: testicular cancer (as a means of palliative treatment and in combination polychemotherapy), ovarian cancer (stages III and IV) squamous cell epithelioma of head and neck (as a palliative remedy) is effective in lung cancer, cancer uroteliyu, cervical tumors.